New York Brain Bank at Columbia University
Alzheimer Disease Research Center
Donor or providing physician:
Answer: NYBB disburses tissue samples to investigating clinicians or scientists, whose research has been approved by their Institutional Review Board (IRB). In addition to sending us a copy of the IRB approval for your study protocol, we request that you submit the signed agreements, which you can download here. After we have reviewed the documents, we will issue an electronic token (i.e. login and password), which will allow you to submit your request via the internet.
Answer: Tissue samples are free of charge, because they are a gift of the donor to scientific research; however, we are forced to charge 100 US Dollars per request for handling the specimens disbursed. However, we must charge you for the shipment of the tissue samples to your laboratory. We are unable to cover the costs in advance, you must provide us with your FedEx account number to bill the shipping costs to you directly.
Answer: Tissue is made available to the scientific community free of charge. However, the NYBB neither sections nor stains tissue samples for investigations which require sections on histology glass slides. If you request samples which require processing by a histology laboratory, we will submit your request to an affiliated laboratory of Columbia University and ask you to cover the fees. For prices, which are subjected to change, refer to Question 4 below.
Answer: Price list for histologic services:
Answer: All diagnoses assigned to brains available for research are part of a drop-down list in the electronic request form.
If the diagnosis you are interested in is not included in the list, it means that no tissue, representative of this diagnosis, is available.
Providing concomitant diagnoses (e.g. tissue of brains with Alzheimer disease as a primary diagnosis and cerebral infarcts as a secondary diagnosis) may decrease the likelihood of finding samples which match your request.
While brains of the desired diagnosis may be part of our inventory, specific regions may not be. We will give you notification as to how much of your request we are able to fulfill before sending you samples.
Answer: The focus of the NYBB is on neurodegenerative disorders (e.g. Alzheimer disease, Huntington disease, Parkinson disease). Samples from brains with primary (e.g. astrocytoma) or secondary (e.g. metastases) tumors are not available. Please refer to the list of diagnoses assigned to brains available for research below:
Answer: Please visit our list of diagnoses to learn about the publications which serve as a foundation of our diagnostic criteria.
Answer: These are the sample types, which usually are available:
Blocks are ideal for investigations requiring preservation of cellular morphology (see below).
Aliquots are suitable for blots, or biochemistry or microassays.
Although less optimal than blocks or aliquots, slices may serve for most investigations.
Their availability is contingent upon the amount of samples harvested for obtaining blocks and aliquots.
Answer: Frozen tissue is stored in freezers at -80 °C. Tissue which is neither frozen nor embedded in paraffin is stored in 10% buffered formalin at room temperature.
Answer: The same prerequisites apply to domestic and foreign institutions. The research project has to be approved by an ethics committee (equivalent of the Institutional Review Board) of the institution (see above). The recipient of the tissue samples will have to cover the shipping costs (see above).
Answer: The average time between the placement of the tissue request and the shipping is two weeks. This is an estimate and does not apply to requests which include samples which have to be collected prospectively or samples from brains with rare diagnoses.
Answer: We will help to solve problems or provide answers to questions you might have with regards to brain banking. Your feedbacks will be welcomed, including any suggestions that could contribute to the improvement of our services. Please be sure that you have read the information on our web site, which covers many related topics. For further assistance please direct your questions or comments to:
NYBB / Taub Institute
Answer: The NYBB has to insure that identifiable health information is protected in accordance with the Health Insurance Portability and Accountability Act. Customarily we provide the following information for all samples:
Answer: The activation of your account will occur shortly after we have received the requested documents and verified the data you provided. As soon as your electronic token is created, you will receive a notification via email. Your token will remain active until the budget period of your grant has ended.
Answer: If the donation of a fresh brain is expected in the near future, please inform us. We will provide you with shipping materials. Should the donation of a fresh brain take place immediately please refer to how to ship the brain to the NYBB.
Answer: Please provide personal information pertaining to the donor and send us a record of the time intervals between the steps of obtaining the brain (e.g. day and time of death, time body in cold room, day and time of removal of the brain, etc). We encourage you to use our sample information sheet. Any clinical data available would be very helpful to us.
Last updated 07/19/2008